Front End Frameworks
The Forme boilerplate theme ships out of the box with Bootstrap 5.3 and jQuery 4.0, however there's nothing to stop you using whatever combination of frameworks you're more comfortable with, or even none at all. Go ahead and npm install as you see fit, and edit vite.config.js as required.
For example in our own projects, we tend to avoid jQuery except for the simplest portfolio sites - currently we favour Stimulus for lighter interactions and widgets, and Vue 3 for more complex use cases like SPAs.
As for the CSS side, it's easy enough to swap out Bootstrap for whatever system you prefer. We currently dig more of a CubeCSS approach with Sass preprocessing and UnoCSS for our utility layer, but there are plenty of options out there.
TODO
Add a vite.config.js example